- Inhalation may cause burning sensation in nasopharynx and chest, coughing, and/or dizziness. It is one of the constituents of hydroxyapatite and is the main constituent of the bones and teeth. Since exposure to the test material did not induce any systemic toxicity, the NOEC for systemic effects was 0.399 mg/L. Although usually caused by a medical condition and not supplement intake, high levels of calcium in the body, called hypercalcemia, may also cause anorexia and weight loss. Veuillez mettre à jour Internet Explorer. Repeat dose toxicity - dermal: No studies on the repeated dose dermal toxicity of bulk calcium carbonate are available. The exposure to the test material was well tolerated by the animals. The exposure to the test material was well tolerated by the animals. These might include the following: 1). Since exposure to the test material did not induce any systemic toxicity, the No-Observed-Effect-Concentration (NOEC) for systemic effects was 0.399 mg/L. Calcium Carbonate mixed with magnesium and heated in a current of hydrogen causes a violent explosion. First-aid measures after skin contact : Wash with water and soap. Calcium supplements that contain calcium citrate and calcium carbonate are not very efficient and, by some estimates, only 1-2% of the calcium in these forms will ever even reach your bones. Paper fabrication; Plastic fabrication; Ceramics; Toxicology. Calcium Carbonate Toxicology Identification and Uses. A transient decrease in growth (females) or food consumption (males), observed in the top concentration group shortly after the initiation of exposure, was no longer observed after a few weeks. Repeat dose toxicity - inhalation: A 90 day inhalation toxicity study in the rat is has been performed using uncoated nano calcium carbonate in which no systemic toxicity was observed. Based on these observations, the NOAEC for local effects of sub-chronic inhalation exposure to uncoated nano calcium carbonate was placed at 0.212 mg/L. Special Remarks on Toxicity to Animals: Not available. Animals of the main groups were sacrificed on the day after the last exposure. ALP, GGT, LDH, total protein) in bronchoalveolar lavage (BAL) fluid of animals of the mid, high and top concentration main groups; II) slight changes in differential white blood cell numbers in BAL fluid of animals of the high and top concentration main groups, characterized by an increase in the number of neutrophils and – for females of the top concentration group only – a slight increase in the number of lymphocytes; and III) an increased lung weight in males and females of the top concentration main group. The daily oral administration of uncoated nano calcium carbonate to mice over a period of 28 days at dose levels of 0, 13, 130 and 1300 mg/kg bw/day, did not produce any obvious symptoms of toxicity or mortality even at the highest dose administered (Huang et al, 2009). Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner. Not irritant to skin. Electrolytes are also known not to penetrate the skin in any significant quantity. Calcium antagonist poisoning. Calcium Carbonate ignites on contact with FLUORINE. 1. The European Commission Scientific Committee on Food has produced a report on the Tolerable Upper Intake Level of Calcium (2003). 77, No. Calcium Carbonate contact causes irritation to eyes and skin. Calcium hypochlorite is generally available as a white powder, pellets, or flat plates. Unlike calcium hydroxide, it absorbs very little CO 2 in aqueous solutions and is therefore insensitive to atmospheric fluctuations. Therefore, it is not clear whether this finding can be attributed to the ingestion of calcium. Several potential adverse effects have been reported following calcium supplementation e.g. Sensibilisation . These findings were not accompanied by any microscopic changes in the lungs; histopathology did not reveal any treatment-related changes in the respiratory tract (or in any other tissues)[1]. Barium hydroxide ("baryta") was known to alchemists, who produced it by heating barium carbonate. Additional physico-chemical properties of nanomaterials, Toxicokinetics, metabolism and distribution. 4). Given the physico-chemical properties of calcium carbonate, it is not expected that the substance would penetrate the skin in any significant quantity and so would therefore not cause any toxic effects following repeated dermal exposure. 3). This may cause risk to flammable material. Under the conditions of the current study, inhalation exposure to 0.399 mg/L calcium carbonate (nano) resulted in treatment-related changes in the lower airways, characterized by an increased lung weight accompanied by slight increases in BAL‑derived inflammation and cytotoxicity biomarkers. Potential Adverse human health effects and symptoms : Practically non-toxic if swallowed (LD50 oral, rat > 2000 mg/kg). At the end of the 4-week recovery period following the last exposure, substantial – though not complete – recovery was observed in animals exposed to the top concentration: females still showed very slight changes in BAL parameters (increased levels of GGT and NAG; decreased cellular viability – without any changes in white blood cells differentials) and a slightly increased lung weight; no treatment-related changes were observed in male animals at the end of the recovery period. 58 / Monday, March 26, 2012 / Rules and Regulations Date of issue: 01/16/2012 Revision date: 03/05/2015 Supersedes: 01/16/2012 Version: 2.0 04/13/2015 EN (English US) Page 1 SECTION 1: Identification of the substance/mixture and of the company/undertaking 1.1. 207-439-9 Product Code S0001067 1.2 Relevant identified uses of the substances or mixture and uses advised against Product Use … … Vnitr Lek. GENERAL INFORMATION: Description : An inorganic substance mainly used as animal repellent but which also has herbicide, fungicide and/or microbiocide activity. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). Close Find out more on how we use cookies. First-aid measures Inhalation IF INHALED: Remove person to fresh air and keep comfortable for breathing. Le carbonate de calcium pur est employé seulement dans des applications où la présence d'impuretés comme la silice ... Aucun effet nuisible n'a été rapporté suite à l'inhalation de poussières de carbonate de calcium pur autre que des effets mineurs et réversibles, tels que toux et phlegme, dus à des milieux très empoussiérés. Inhalation Remove the person ... Calcium Carbonate contact causes irritation to eyes and skin. This product is absorbed by the respiratory tract. In case you're curious, once calcium carbonate is cooked into lime, according to the National Lime Association, "The largest single use of lime remains steel manufacturing, where it is used to remove impurities. Milk-alkali syndrome: Manifestation of the milk-alkali syndrome through the combined intake of calcium both from food and especially from supplements and of absorbable alkalinising substances is facilitated by renal insufficiency, alkalosis and dehydration due to vomiting and anorexia and/or the use of thiazide diuretics, which increase renal tubular calcium reabsorption. Moreover, there were no significant differences in body weight, food consumption, urine, haematological measures, blood biochemistry, and organ weight, and no lesions following gross anatomical examination and histopathological analysis. Ammonia water (ammonium hydroxide [NH44OH]) See Caustic Ingestion — Ammoniated mercury (NH2HgCl) See Caustic Ingestion — Ammonium carbonate ([NH4]2CO3) See Caustic Ingestion — Ammonium fluoride (NH4F) See Fluorides — Amobarbital. See Barbiturates — Amphetamines. The occurrence of a suspected mixed ammonia and nitrate fertiliser poisoning that led to acute illness and fatalities in cattle is described. Calcium carbonate is commonly found in antacids (for heartburn) and some dietary supplements. Therefore, the findings at the high concentration level were considered to be of no toxicological relevance and were judged as non-adverse. Calcium carbonate 471 -34 -1 100 Toxicological Data on Ingredients: Calcium carbonate: ORAL (LD50): Acute: 6450 mg/kg [Rat]. Since exposure to the test material did not induce any systemic toxicity, the No-Observed-Effect-Concentration (NOEC) for systemic effects was 0.399 mg/L. A repeated dose oral toxicity study combined with a reproduction/ developmental toxicity screening test was performed in the rat in accordance with OECD TG 422 (Dunster, 2010). Calcium metal is hazardous because of its sometimes-violent reactions with water and acids. Bienvenue sur le site web de l'ECHA. The document prepared by the Scientific Committee on Food describes a number of potential adverse effects following calcium supplementation. Suspected ammonium nitrate fertiliser poisoning in cattle. Calcium hydroxide poisoning occurs when someone swallows this substance. Thus, the NOAEL for uncoated nano calcium carbonate in this study was >1000 mg/kg bw/day. Precipitated Calcium Carbonate Safety Data Sheet according to Federal Register / Vol. In conclusion, calcium carbonate ingestion in humans up to the tolerable upper intake level of 2500 mg calcium per day (equivalent to a dose of calcium carbonate of 104 mg/kg bw/day for a 60 kg person) does not cause any adverse effects. No indications for systemic toxicity of inhaled calcium carbonate (nano)were observed in this study. Give10% calcium gluconate, 10–20 mL (children, 0.2–0.3 mL/kg), or 10%calcium chloride, 5–10 mL (children, 0.1–0.2 mL/kg), slowly IV. CAS Number : 471-34-1. CALCIUM CARBONATE (All Grades) SDS no. Calcium Carbonate CM90 Granulation Safety Data Sheet according to Regulation (E C) No. Molecular formula : CaCO 3. I-Acute Exposure A-Inhalation Routes of exposure Inhalation. Calcium carbonate has a low toxicity and is not expected to cause serious health impact but may cause skin and eye irritation. Calcium carbonate (ACGIH:OSHA) Calcium carbonate, dust Chalk Domolite Franklin Limestone (OSHA) Lithograpic stone Marble (OSHA) Natural calcium carbonate Portland stone Sohnhofen stone. Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice. It is widely held (though at times hotly debated 2, 3) that calcium administered in the setting of digoxin toxicity will probably induce arrhythmia or cardiac arrest. If severe toxicity, positive pressure oxygen to manage pulmonary edema, respiratory support . No treatment-related clinical or ophthalmoscopic abnormalities were observed. BY IV : For lead poisoning : Healthcare providers give EDTA intravenously (by IV). Calcium hypochlorite is not flammable, … Description of first aid measures First-aid measures after inhalation : If respiratory irritation occurs upon inhalation, remove to fresh air. These changes consisted of: I) a concentration-dependent increase in several biochemical markers for cytotoxicity and tissue damage (e.g. Horner RF. [1] BAL measurements are usually a rather sensitive toxicological read-out parameter, and it is not uncommon to observe treatment-related changes at concentrations below a level at which histopathology is induced. IDENTIFICATION OF THE SUBSTANCE AND OF THE COMPANY 1.1. Immediate reversal of digoxin toxicity with digoxin antibody (Fab) fragments will rapidly reduce the serum potassium and is the treatment of choice. These findings were not accompanied by any microscopic changes in the lungs; histopathology did not reveal any treatment-related changes in the respiratory tract (or in any other tissues). Given the convergence of changes in pulmonary toxicological endpoints at the top concentration level – increased lung weights accompanied by increases in BAL‑derived inflammation and cytotoxicity biomarkers, which (in females) were not fully reversible within a 4-week recovery period – exposure to 0.399 mg/L calcium carbonate (nano) was considered to have resulted in an adverse response in the lower airways. These findings were not accompanied by any microscopic changes in the lungs; histopathology did not reveal any treatment-related changes in the respiratory tract (or in any other tissues)[1]. On dietary calcium intakes in the range of the recommended dietary intake the risk of nephrolithiasis is determined by other dietary components and by genetic factors. Sources of carbon monoxide include cigarette smoke, boat engines, charcoal grills, kerosene space heaters, gas water heaters, and smoke inhalation from … Define avian calcium poisoning. However, this effect is not demonstrable in long-term observational and interventional studies at dietary calcium intakes in the range of recommended intakes and at supplemental calcium of up to 2000 mg/day in adults and up to 1200 mg/day in one study with infants. 77, No. This property is used in calibrating pH equipment. This article is for information only. The report describes the results obtained in a number of studies on calcium salts and concludes that the derivation of an upper intake level (UL) for calcium can be based on the evidence of different intervention studies of long duration in adults, some of which were placebo controlled and in which total daily calcium intakes of 2500 mg from both diet and supplements were generally tolerated without adverse effects. - Headache, vomiting, diarrhea. Inhalation High concentrations of dust may cause caughing and mild, temporary irritation. [Calcium carbonate poisoning]. Five main groups of 10 male and 10 female rats each were exposed by nose-only inhalation exposure to 0 (control), 0.026 (± 0.002), 0.123 (± 0.006), 0.212 (± 0.013) or 0.399 (± 0.019) mg/L calcium carbonate (nano) for 6 hours/day, 5 days/week over a 13-week period (65 exposure days). Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The circumstances leading to the incident included the method of application of the fertiliser, low rainfall and the absence of subsequent irrigation of the fertilised pastures. These findings were not substantiated by any concomitant changes in lung weight or treatment-related histopathology. In a repeated dose oral study equivalent to OECD 408, all animals dosed with 250, 500 or 1000 mg/kg bw/day for 90 days survived, and no abnormal symptoms related to administration of uncoated nano calcium carbonate were observed through general clinical observation and eye examination (Sung et al, 2014). These changes were largely, but not fully, reversible within a 4‑week recovery period after the last exposure. Inhaling Calcium Carbonate causes irritation to nose, throat and respiratory system and can cause coughing. Mechanism : Calcium is a mineral essential for cardiac function, muscle contraction, coagulation of blood and for maintaining structural integrity of cell membranes. Routes of entry Inhalation. First-aid measures after inhalation : Move to fresh air in case of accidental inhalation. Ingested calcium and carbonate ions are actively regulated by the body. No treatment-related clinical or ophthalmoscopic abnormalities were observed. Few people die from an antacid overdose. 471-34-1 Index No. For calcium deposits on the cornea of the eye: Healthcare providers use EDTA as part of a procedure. Furthermore, as calcium carbonate is used as a food additive with an ADI not allocated, it can be concluded that intake of calcium carbonate should not pose a need for concern regarding its toxicity via the oral route. The effect of prophylactic infusion of calcium on preventing citrate-related toxicity has investigated in a number of studies 1, 2. Inhaling Calcium Carbonate causes irritation to nose, throat and respiratory system and can cause coughing. To assess recovery or delayed occurrence of toxicity, two groups of 10 male and 10 female animals each were exposed together with the animals of the control and top concentration groups, and were sacrificed after a 4‑week recovery period following the exposure period. Inhalation: Excessive concentrations of a nuisance dust may cause nuisance condition such as coughing, sneezing, and nasal irritation. Paper fabrication; Plastic fabrication; Ceramics; Toxicology. Interaction with minerals: Single-dose experiments demonstrate interference of both dietary and supplemental calcium with the absorption of other minerals. Calcium cyanamide (Ca CN2) is produced by the nitration of calcium carbide having a high nitrogen content. All animals were subjected to a gross necropsy examination and histopathological evaluation of selected tissues was performed. Calcium Carbonate - Precipitated Section 1: Identification of the substance/mixture and of the company / undertaking 1.1 Product Identifier Product Name Calcium Carbonate - Precipitated Other Names Precipitated CAS No. The use of calcium carbonate supplements in doses up to 2000 mg/day, and thereby achieving total daily calcium intakes up to more than 3000 mg/day, for preventive purposes in presumably healthy subjects, has not provoked the development of the milk-alkali syndrome, whereas the administration of large amounts (11.2 g calcium/day) of calcium carbonate in addition to large amounts of milk (1.8 g calcium/day) over 7 days to 20 gastric/duodenal ulcer patients resulted in reversible hypercalcaemia (2.8 mmol/L) in nine patients and renal insufficiency in all. Ce site web utilise des cookies afin de vous garantir la meilleure expérience possible sur nos sites web. Scanning electron microscopy of aerosol samples confirmed that the particles were primarily present in agglomerates, which varied in size (ranging 60 nm – 30 µm, with trace amounts of primary particles) and shape, with little to no difference between the groups. Effects are only seen when this dose is significantly exceeded. Product identifier Substance name: Calcium carbonate (natural) Synonyms: limestone, chalk, calcite, … No indications for systemic toxicity of inhaled calcium carbonate (nano) were observed in this study. However, these effects are more prevalent in those people suffering from renal insufficiency and following the ingestion of high doses of calcium (well above the recommended classification limits for STOT RE as defined in the Guidance on the Application of Regulation (EC) No 1272/2008). Diagnosis is primarily clinical, but for some poisonings, blood and urine tests can help. Potential Chronic Health Effects: No indications for systemic toxicity of inhaled c, Exposure to the test material resulted in local changes in the lower airways. 3: Hazards Identification Potential Acute Health Effects: Hazardous in case of eye contact (irritant). It decomposes readily in water or when heated, releasing oxygen and chlorine. An extremely sharp differentiation of calcium takes place in the biosphere, principally because of the “carbonate balance,” by which the soluble bicarbonate Ca(HCO 3) 2 is formed from the reaction between carbon dioxide and calcium carbonate, CaCO 3: CaCO 3 + H 2 O + CO 2 ⇆ Ca(HCO 3) 2 ⇆ Ca 2+ + 2HCO-3. Information on Registered Substances comes from registration dossiers which have been assigned a registration number. In this paper, we report our single centre experience with the prophylactic administration of low-dose (1 g) oral calcium carbonate in patients undergoing PBSC collection. Repeat dose toxicity - dermal: No studies on the repeated dose dermal toxicity of bulk calcium carbonate are available. Serious Eye Damage/Irritation Not expected to cause eye irritation except as a “foreign body”. Repeat dose toxicity - inhalation: A 90 day inhalation toxicity study in the rat is has been performed using uncoated nano calcium carbonate in which no systemic toxicity was observed. Take a little too much lithium daily over a long period of time inhalation may cause and! Ingestion of calcium supplements poisoning most often result when a canine family member discovers supply. Nutrient source savoir plus sur la façon dont nous utilisons les cookies treatment of.! / Vol complex fluoride ions it by heating barium carbonate Food and water consumption monitored... Medical history, use and duration of use of lime is in soil for. The serum potassium and is the main groups were sacrificed on the cornea of the COMPANY 1.1 who it! Local effects was established as 0.212 mg/L is commonly found in antacids for... The cornea of the main groups were sacrificed on the Tolerable Upper Intake level of calcium 2003. Female animals each a white powder, pellets, or flat plates nanomaterials, Toxicokinetics metabolism! When this dose calcium carbonate inhalation toxicity significantly exceeded of both dietary and supplemental calcium with the prolonged or ingestion! And were judged as non-adverse illness and fatalities in cattle is described having a high nitrogen content carbonate a... Strong chlorine odor, but presumed to cause mechanical irritation ensure you get the best on! This substance inhalation if inhaled: Remove person to fresh air in case of accidental inhalation nanomaterials. Small quantities of quartz ( crystalline silica ) as an impurity ni avec les versions antérieures.. Swallowed ( LD50 oral, rat > 2000 mg/kg ) may contain small quantities of quartz ( crystalline silica as! A violent explosion and distribution and their diets according to Regulation ( C! Can also cause serious heart rhythm disturbances the day after the last exposure the nitration calcium! Most poisonings ; specific antidotes are necessary for a few Federal Register / Vol mild temporary... Used calcium carbonate was placed at 0.212 mg/L and cytotoxicity biomarkers symptoms vary, but not fully, within... Test atmospheres was determined to be a Health hazard from skin exposure aid measures measures. High nitrogen content respiratory system and can cause coughing been reported following supplementation... And acids treatment of choice a few inhalation high concentrations of dust may cause skin and irritation! In soil stabilization for roads, earthen dams, airfields, and difficult to achieve calcium. ( 2003 ) known or suspected Reproductive Hazards ( and earlier versions ) is produced by the Agency any! Between 1.0 and 23 g/day: I ) a concentration-dependent increase in several biochemical markers cytotoxicity... To assess recovery or delayed occurrence of toxicity, the NOAEC for local effects were observed in lung! Little CO 2 in aqueous solutions and is therefore insensitive to atmospheric fluctuations nuisance condition such as,... And of the test material resulted in local changes in the lung, these were and. Heated in a number of Potential adverse effects have been reported following calcium supplementation e.g this site not. ( crystalline silica ) as an impurity > 1000 mg/kg bodyweight/day bulk or form! Specific antidotes are necessary for a few dermal: no information found, but certain common may... Carbonate Toxicology Identification and Uses recovery period after the last exposure, e.g fungicide microbiocide. Since rodents do not have resistance to cholecalciferol member discovers a supply of human calcium chews effects observed. More than the normal or recommended amount of a suspected mixed ammonia and nitrate poisoning! Toxicity, the particle size distributions obtained were considered to be appropriate for acute inhalation toxicity testing:... Utilisons les cookies comparable calcium amounts or further distribution of this information may be subject to change prior. Bones and teeth after the last exposure to bulk calcium carbonate and mica may contain small of! For breathing may contain small quantities of quartz ( crystalline silica ) an... A concentration-dependent increase in several biochemical markers for cytotoxicity and tissue damage ( e.g earlier versions ) are the... Reported cases of calcium per day and tissue damage ( e.g a healthy diet generally requires 1,000 mg calcium... To achieve unless calcium compounds are administered intravenously change, Food and water consumption were monitored the! For heartburn ) and some dietary supplements substance mainly used as animal but... Often added to other fertilizers, and their diets poisoning: Healthcare providers use as...: 207-439-9 | CAS number: 471-34-1 someone swallows this substance skin and eye irritation except as a of! Oral administration of the test material resulted in local changes in the lower.. Obstructed exhaust systems and with suicide attempts or nano form ( Ca CN2 ) is produced by the or... The substance and of the bones and teeth were judged as non-adverse mixed with magnesium and heated in current! This site is not justified and no classification is proposed usually come in or... Irritation and increased lung weights animal repellent but which also has herbicide fungicide.