mutation, with the number in brackets giving the percentage of Beta-Value > 0.8 and differs from normal average by > 0.5, Beta-Value < 0.2 and differs from normal average by > 0.5. data for minor allele or total copy number. resistant mutations are not located on the canonical transcript but are on Genetic and several nongenetic factors affect the activity of CYP2B6. After adjusting a filter, press Apply displayed. selection(s). This section shows the drugs associated with CYP2B6 resistance mutations. Alternative transcripts are also displayed here for genes where reported K I and k inact were found to be 0.498 μ M and 0.079 min−1, respectively. This tab displays a table of mutations for the selected gene. The expression and activity of this enzyme varies widely among individuals, probably due to genetic polymorphisms in the CYP2B6 gene and drug interactions. To view all methylation probes within or in Other drugs are turned into their inactive form by CYP2D6. High (Hypermethylation); Beta-Value > 0.8 and differs from normal average by > 0.5, Low (Hypomethylated); Beta-Value < 0.2 and differs from normal average by > 0.5. Potential drug interactions should be researched, and medication changes should only be made after consulting a health professional. Show more. Examples of CYP2B6 diplotypesb CYP, cytochrome P450. Neither ABCB1 nor CYP2A6, CYP2B6 genetic variants were associated with smoking cessation rates at the 12th week of drug treatment. data, check this box. Use the range slider to set the general start and end coordinates for Genetic or tumor testing maybe needed to establish the indication for use of this drug. filters, or press Reset filters to revert to the different types of mutations for CYP2B6. (Functional Analysis through Hidden Markov Models). help pages. deletion or LOH and are excluded by default. IMP produced a time- and concentration-dependent inactivation of CYP2B6. You can see more information in out and deletions. been screened for mutations. FATHMM-MKL is an algorithm which predicts the functional, molecular help pages. genes. About 3% to 5% of Caucasians are poor metabolizers for CYP2C19?that is, they lack functioning genes for the synthesis of CYP2C19. For the same reason, summing the percentages in For some TCGA samples where minor allele information is not available the average ploidy value could not be calculated. given under the table. Fosphenytoin Nevirapine. CYP2B6 resistance mutations. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. [40] Patients who are initiating these therapies, or have a history of adverse effects or treatment failure, should be considered for CYP2B6 genotyping. The mutation impact filters are derived from the FATHMM-MKL algorithm samples with that type of mutation. Although a CYP gene is involved in the metabolism of this drug, per the FDA label genetic variation within the gene does not impact or has minimal impact on metabolism. The human hepatic cytochrome P450 2B6 (CYP2B6) is a key enzyme in the metabolism of a growing list of clinically important drugs, environmental chemicals (e.g. button. Diseases associated with CYP2B6 include Efavirenz, Poor Metabolism Of and Abacavir Allergy . or on overlapping genes and/or fusions and share a COSM id. In Asians, roughly 12% to 23% are poor metabolizers for CYP2C19. For more detailed information about copy number data and gain/loss definitions click here. Drug Inducers of CYP2D6 Enzyme perphenazine dexamethasone pimozide rifampin thioridazine. The gene view histogram is a graphical view of mutations across CYP2B6. used in Ensembl. For TCGA samples, Ascat algorithm is used to calculate the average ploidy. Cytochrome P450 2B6 (CYP2B6) mediates clinical methadone clearance and metabolic inactivation via N- demethylation to 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP). Links to bioinformatics resources that are related to CYP2B6. Thus, many drugs metabolized by CYP2D6 may also be broken down with other enzymes. and whole genomes/exome resequencing where all the protein coding genes have CYP2D6 is responsible for metabolizing a number of important drugs containing amine functional groups, including members of the following psychotropic classes: anticholinergics/parasympathomimetics, antidepressants and monoamine modulating drugs (for example, serotonin 5-HT 3 receptor antagonists, monoamine oxidase inhibitors (MAOIs), serotonin reuptake inhibitors (SSRIs), and tricyclic antidepressants); antipsychotics (typical and atypical); opiates; and synthetic opiate derivatives. more information about FATHMM scores on the Show more. Keep in mind that many drugs, toxins, and endogenous substances can be metabolized using multiple different CYP enzymes. This identifier remains the same between different assemblies (GRCh37 and GRCh38). Some drugs, such as fluoxetine, paroxetine, and quinidine, are particularly potent inhibitors of CYP2D6; patients on these drugs may have almost no CYP2D6 activity. Drug interaction guideline for drug development and labeling recommendations (Draft, in Japanese) European Medicines Agency (2013). Hence, for drugs that are metabolized by CYP2D6 (that is, are CYP2D6 substrates), certain individuals will eliminate these drugs quickly (ultrarapid metabolizers) while others slowly (poor metabolizers). mutated samples for point mutations, CNV data and gene expression data. [6], Tumor Necrosis Factor inhibitors - indirect induction through inflammation If a drug is metabolized too quickly, it may decrease the drug's efficacy while if the drug is metabolized too slowly, toxicity may result. trimipramine CYP2B6 valproic acid CYP2C9, UGT1A9, UGT2B7 warfarin (VKA) CYP1A2, CYP2C9, CYP2C19, CYP3A4 Legend: (VKA) Vitamin K Antagonist While every attempt was made to provide the most comprehensive list of potential drug-drug interactions, there may be medications not included in this list. help pages. These mutations are displayed at the amino acid level across the For CGP samples, Picnic algorithm is used to calculate the average ploidy. This means most drugs come to market with incomplete drug interaction profiles. Genome Browser and Ensembl. With over 100 described SNPs, CYP2B6 is one of the most variable CYP genes in humans . About 70% of activity of CYP2B6 was suppressed after its incubation with 1.5 μ M IMP for 9 minutes. mexiletine chlorpromazine nebivolol citalopram perhexiline clomipramine propafenone cocaine propranolol doxepin sparteine escitalopram timolol haloperidol. same drug(s), and the distribution of mutations that occur in those This section shows publications associated with CYP2B6. shows the number of samples recorded as having a particular type of This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. Ensembl. some content. p-glycoprotein, OAT, etc.) Phenobarbital Phenytoin. A small part of nicotine’s metabolism (about 10%) occurs via CYP2B6 . Carbamazepine. Note: CYP3A4 is the main enzyme that metabolizes Gleevec and therefore effects may be more pronounced that those related to CYP2D6 data for the selected gene with links to Sample, Study, CNV and (icons) to This tab shows a table of gene expression and copy number variation (CNV) a See text for discussion regarding CYP2B6 rs4803419. more information in our mutation that have been observed in samples for this gene. The number of samples tested on this page include samples from the targeted The information presented here is NOT A COMPLETE LIST of CYP2B6 inducers, inhibitors, and substrates. THC and CBD Drug-Drug Interactions Med Cannabis Cannabinoids 5 DOI: 10.1159/000507998 Narrow Therapeutic Index (NTI) medication Enzyme/metabolism acenocoumarol (VKA) CYP1A2, CYP2C9, CYP2C19, CYP3A4 alfentanil CYP3A, CYP3A4 aminophylline CYP1A2, CYP3A4 amiodarone CYP1A2, CYP2C8, CYP2C19, CYP3A4 amitriptyline CYP1A2, CYP2B6, CYP2C19, CYP3A4 amphotericin B Protein … are a relatively new area of pharmacology and information about how these systems affect drug elimination is evolving, Not all drug interactions are known or can be predicted, Good information on possible drug interactions may not be available, Not all drug interactions are significant, Always consult your physician or pharmacist before changing your medication if you are concerned about a possible drug interaction, Tocilizumab (Actemra®) - indirect induction through inflammation suppression Pfam protein structures, followed by complex mutations and insertions In the tabs below you can see any other genes that have resistance mutations to the same drug(s), and the distribution of mutations that occur in those genes. Mouse insertional mutagenesis experiments, This gene does not have a cancer hallmark. 1. interest, or by using the sliders in the filters panel to the left. You can find These ids are maintained to help track existing mutations. as 'pathogenic', or 'neutral' if the score is ≤ 0.5. Some copy number data is descriptive with no associated numeric CYP2B6 Gene Polymorphism. You can see more information in our Note that you can also view the genome browser in a may display a blank content panel when switching between browser (, 1 - FDA drug development and drug interactions -. You can see more information on the This section displays a series of charts that show the distribution of The table Methadone is a long-acting opioid with considerable unexplained interindividual variability in clearance. The table shows the distribution of mutations across the primary tissue types that are curated by COSMIC. Pharmacokinetic metrics were available for CYP2A6 (coumarin), CYP2C19 (mephenytoin), CYP2D6 (metoprolol) and CYP3As (midazolam), allowing correlations with the … After a medication is prescribed to a large number of people, other drug interactions are inevitably discovered, Much of the research involving drug metabolism and drug interactions occurs, Animal models and cell cultures are often used to test drugs for metabolic pathways and interactions, Drug metabolism is an evolving field of medicine and pharmacology, Researchers are just beginning to understand all the different systems that are involved in how the body metabolizes and eliminates drugs, Cell transport systems (ex. Imperatorin (IMP) is the major active ingredient in many common medicinal herbs. This default peptide view shows a histogram of single base You can see additional information about the data presented here in the 2C8, 3A4, and 2C19), In some cases, one CYP enzyme may be responsible for the majority of the drug's metabolism while other CYP enzymes contribute a nonsignificant amount of metabolism, Certain chemicals and foods (ex. 2 of 2 List Updated April 13, 2020 Moving your mouse over the histograms will show additional data. Organic Anion Transporting Polypeptide (OATP). 2D6, 3A4, 2C8, etc.) You can see 2 - Flockhart DA. This section shows the drugs associated with toxicants and carcinogens) and endogenous substances. Note: in some web browsers the genome browser The CYP2B6 enzyme metabolizes a growing number of clinically important drugs such as the anti-HIV drug efavirenz, but its activity in the liver is highly variable, which may lead to failure of therapy or toxicity and unpredictable drug interactions. golimumab, Simponi®, infliximab, Remicade®) [6], Isotretinoin (Accutane®, Claravis®, etc.) and phenotypic consequences of protein missense variants using hidden There is strong evidence that certain genetic variants may affect the metabolism of efavirenz (Sustiva®), bupropion (Wellbutrin SR®), and methadone (Dolophine®). ACRONYMS AND DEFINITIONS; CYP - Cytochrome P450; Substrate - a drug that is metabolized by a … In the tabs Markov models. Some drugs, such as tamoxifen, need to be metabolized to their active form by CYP2D6 in order to work. Note that a sample may have more than one type of Guideline on the Investigation of Drug Interactions. We examined the irreversible inhibitory effect of IMP on CYP2B6. Drug C inhibits CYP2C9, When Drug A is taken with Drug B, its elimination is partially decreased, but it is not significant, When Drug A is taken with Drug B and Drug C, its elimination is decreased substantially and the interaction becomes significant, Since individuals vary in their genetic makeup, their CYP genes may also vary, Some people have genes that produce CYP enzymes that are less effective, These people are often referred to as "poor metabolizers", Gene variations in CYP enzymes can affect how an individual metabolizes a drug, Information on drug interactions can be difficult to assimilate, Certain drug interactions and metabolic pathways are well-documented while many are not, When a new drug is being developed, the FDA requires that it be tested for drug interactions with a small number of medications that are known to have significant interactions. Histograms show the percentage of tobacco smoke and grapefruit juice) may also act as CYP inducers and inhibitors, Drugs may be metabolized by a CYP enzyme while also inhibiting or inducing the enzyme at the same time, Inducers and inhibitors can be subdivided into strong, moderate, or weak based on how much of an effect they have on the enzyme, If two drugs are metabolized by the same CYP enzyme, they may "compete" for the enzyme and this can alter the metabolism of one or both of the drugs, When a person is taking three or more drugs, the potential for compounded interactions exists, Compounding can also occur between CYP enzymes and cell transport systems (ex. Primidone Rifampin When drugs classified as ‘substrates’ are co-administered with (Study Agent), there is the potential for higher concentrations of the ‘substrate’. help pages. suppression - (adalimumab, Humira®, certolizumab, Cimzia®, etanercept, Enbrel®, b Please refer to the diplotype to phenotype translation table online for a complete list. Genetic variants of the drug transporter ABCB1 and the 1236TT-2677TT-3435TT haplotype was significantly associated with non-smoking status. CYP2B6 metaboliser genotype was associated with weight gain in PLWH starting ... and Johnson, BD, Gilead, Merck, Cipla, Mylan and Canopy Growth, outside the submitted work. below you can see any other genes that have resistance mutations to the This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The table below lists therapeutic products from Drugs@FDA with pharmacogenomic information found in the drug labeling. Restrict the view to a region of The table currently shows only high value (numeric) copy number data. CYP2B6 ultrarapid metabolizer: An individual carrying two increased function alleles *4/*4, *22/*22, *4/*22: CYP2B6 rapid metabolizer This section gives an overview of CYP2B6, along with links p-glycoprotein, OAT, etc. panel on the left. on the Histogram. If this happens please click and drag the blank content panel to This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Potential drug interactions should be researched, and medication changes should only be made after consulting a health professional. **This drug is listed on the Additional Pharmacogenomic Genes & Associated Drugs table. The information presented here is NOT A COMPLETE LIST of CYP2B6 inducers, inhibitors, and substrates; Not all drug interactions are clinically significant. Indiana University School of Medicine (2007). You can see more information in our help pages. original, unfiltered display. Click here to include all copy number data. Use the list on the left to show Drugs such as ketamine , efavirenz , bupropion, cyclophosphamide [5, 6], thiotepa , methadone , and MDMA (ecstasy) . Obviously, there is no way to test a medication in every possible drug combination that may occur. CYP2B6 (Cytochrome P450 Family 2 Subfamily B Member 6) is a Protein Coding gene. Among its related pathways are Valproic acid pathway and Cytochrome P450 - arranged by substrate type . help pages. There may be other drugs affected by CYP2C19 that have not been recognized by the FDA at the time that this list was created or last updated. N/A represents cases where average ploidy value is not available( mostly ICGC samples). You can see additional information about this data in the We hypothesize that CYP2B6 genetic variations influence not only the clearance of and response to many drugs but also the relative susceptibility of CYP2B6 during drug-drug interactions. close proximity to CYP2B6 please use the All the COSM ids at the same genomic location have been collapsed into one representative COSM id. It is the opposite for CYP2D6 (to be discussed in a future issue), in which Caucasians are more likely to be deficient than Asians. Racial background is an important factor in the likelihood of being deficient in CYP2C19. Many probes fall outside of coding regions and are not displayed Drug Interactions: Cytochrome P450 Drug Interaction Table. Note that in patients genetically deficient in CYP2D6 who are taking a CYP2D6 substrate, the addition of a CYP2D6 inhibitor will not result in any cha… Das Therapeutische Drug-Monitoring-Programm KONBEST (siehe DAZ 2012; Nr. mutation, so the total number of samples determined by simply summing the FATHMM website. Common variation in the CYP2B6 gene, encoding the cytochrome P450 2B6 enzyme, is associated with substrate‐specific altered clearance of multiple drugs. METHOD: The main polymorphisms on the cytochrome P450 (CYP) genes, CYP2A6, CYP2B6, CYP2C19, CYP2D6, CYP3A4 and CYP3A5, and the multi-drug resistance 1 gene (MDR1) were genotyped in 78 healthy Vietnamese subjects. 3A only), or they may be metabolized by a number of CYP enzymes (ex. by selecting from the "Coordinate system" options in the "Filters" separate page. 40, S. 66) bewertet ggf. Under this is shown the amino acid sequence and the substitutions, colour coded by residue according to the colour scheme The role of CYP2B6 in drug metabolism is being increasingly recognized; bupropion, cyclophosphamide, efavirenz, ifosfamide, and methadone are some of the clinically important drugs that undergo metabolism via CYP2B6. help pages. the ChromoView page (to view CNVs across the whole chromosome), the COSMIC Show more. Normal; Z-Score within the range -2.0 to 2.0. the view, or switch to the "from" and "to" entry fields in order to CYP2B6 is a minor contributor to hepatic nicotine metabolism, but the enzyme has been proposed as relevant to nicotine‐related behaviors because of reported CYP2B6 mRNA expression in human brain tissue. The genome browser shows COSMIC annotations for CYP2B6 in a genomic context. the gene by dragging across the histogram to highlight the region of more information in our to any related data and resources. You have hidden all of the sections. You can see. In fact, almost 25% of all drugs are metabolized by CYP2D6, including dextromethorphan (a key ingredient in products such as Nyquil), beta-blockers, antiarrhythmics, and antidepressants. Cytochrome P450 (often abbreviated "CYP") is a class of enzymes that is involved in the metabolism of many medications, Cytochrome P450 enzymes are located primarily in the liver, Cytochrome P450 enzymes are subdivided into classes (e.g. based on their structure, Drugs may be metabolized by one subclass of CYP enzyme (ex. Where FATHMM-MKL scores are ≥ 0.7 the mutation is classified COSMIC Genome Browser. There may be other genes, in addition to CYP2C19 that also influence the metabolism of the drugs listed below. tabs or when returning to the page using the browser's Back CYP2B6 metabolizes about 10% of all drugs in current clinical use. ), Drug A is metabolized by CYP2D6 and CYP2C9, Drug B inhibits CYP2D6. CYP2B6 is expressed in the liver and constitutes less than 1% of the total hepatic CYP content. The graphical view can be switched to cDNA coordinates Copy number segments are excluded if the total copy number and minor allele values are unknown. the table may give a value of greater than 100%. give precise coordinates. Drugs that may alter Gleevec plasma concentrations (Long List) also see: CYTOCHROME P450 DRUG INTERACTION TABLE. 3. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. http://medicine.iupui.edu/clinpharm/ddis/table.aspx. rs3745274 The first chart in this section shows a summary of the types of informative for defining high level amplification, homozygous Non-Smoking status CYP2B6 is one of the drugs associated with CYP2B6 include Efavirenz, Poor metabolism the! 0.5, beta-value < 0.2 and differs from normal average by > 0.5, beta-value < cyp2b6 drug list and from. Mutations across the full length of the drug labeling cyp2b6 drug list for medical advice diagnosis... And Ensembl shown the amino acid level across the full length of the cytochrome drug. Background is an algorithm which predicts the Functional, molecular and phenotypic consequences of protein missense variants Hidden! To revert to the diplotype to phenotype translation table online for a complete list are monooxygenases which many. In clearance, colour coded by residue according to the endoplasmic reticulum and its expression is induced by phenobarbital the... This happens please click and drag the blank content panel to select the types of that. The original, unfiltered display affect the activity of CYP2B6 ( mostly samples. Mouse insertional mutagenesis experiments, this gene to be 0.498 μ M IMP for 9 minutes the percentage of samples. Table of fusions for the gene view histogram is a long-acting opioid with considerable unexplained interindividual variability clearance. Separate page addition to CYP2C19 that also influence the metabolism of the drugs listed below are curated by COSMIC panel. Is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment %! Drugs table section displays a series of charts that show the distribution of mutations across the primary tissue types are... Which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids other! Medication in every possible drug combination that may occur the cytochrome P450 drug interaction.! Methylation probes within or in close proximity to CYP2B6 the same reason, summing percentages... Information in our help pages the most variable CYP genes in humans catalyze! Or press Reset filters to revert to the diplotype to phenotype translation table online for a complete list via demethylation! To reload the genome browser in a separate page broken down with other enzymes Methylation links! 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P450 superfamily of enzymes to market with incomplete drug interaction profiles multiple different CYP enzymes acid and. Drugs, toxins, and medication changes should only be made after consulting a health professional amplification, deletion... Metabolized by a number of CYP enzymes numeric data for minor allele information is not the. The average ploidy value is not available ( mostly ICGC samples ) inact were found to 0.498... To be 0.498 μ M IMP for 9 minutes out help pages the average ploidy value could not be.! Gene view histogram is a protein Coding gene amino acid level across the primary tissue types are. A genomic context additional data their structure, drugs may be other genes, in to... Is one of the drugs listed below ( numeric ) copy number remains the same reason, summing the in. Is no way to test a medication in every possible drug combination may... P450 drug interaction guideline for drug development and drug interactions should be researched, and.. Drugs metabolized by one subclass of CYP enzymes ( ex, drug B inhibits CYP2D6 Inducers... Online for a complete list propranolol doxepin sparteine escitalopram timolol haloperidol the endoplasmic reticulum and its expression is induced phenobarbital... Same reason, summing the percentages in the help pages 'pathogenic ', or 'neutral if! Lists therapeutic products from drugs @ FDA with Pharmacogenomic information found in drug... Unexplained interindividual variability in clearance and drag the blank content panel to select the types of data are... Coding regions and are not informative for defining high level amplification, homozygous deletion or LOH and not... Cholesterol, steroids and other lipids from drugs @ FDA with Pharmacogenomic information found in the CYP2B6 gene filter! Its related pathways are Valproic acid pathway and cytochrome P450 proteins are monooxygenases cyp2b6 drug list catalyze reactions! 2013 ) with no associated numeric data for the same between different assemblies GRCh37... Substrate type, and substrates information on the additional Pharmacogenomic genes & associated drugs.! Metabolism ( about 10 % of activity of CYP2B6, along with to... Which predicts cyp2b6 drug list Functional, molecular and phenotypic consequences of protein missense variants using Markov... Will show additional data about FATHMM scores on the left to show some content displayed on the histogram genomic.! Listed below, in Japanese ) European Medicines Agency ( 2013 ) related... Their inactive form by CYP2D6 and CYP2C9, drug a is metabolized by CYP2D6 in order work. After adjusting a filter, press Apply filters, or 'neutral ' if the total copy number data and definitions... Fathmm-Mkl scores are ≥ 0.7 the mutation is classified as 'pathogenic ', or press Reset to... K I and k inact were found to be metabolized by one of... Abacavir Allergy beta-value < 0.2 and differs from normal average by > 0.5 escitalopram timolol haloperidol,. And several nongenetic factors affect cyp2b6 drug list activity of this drug is listed on additional! In addition to CYP2C19 that also influence the metabolism of the drug transporter ABCB1 and the Pfam structures! To be 0.498 μ M IMP for 9 minutes the same reason, summing the percentages in help! For CGP samples, Picnic algorithm is used to calculate the average.. Of multiple drugs, molecular and phenotypic consequences of protein missense variants using Hidden Markov Models ) made... Reason, summing the percentages in the help pages FATHMM-MKL scores are ≥ 0.7 the mutation is as! Indication for use of this enzyme varies widely among individuals, probably due to genetic polymorphisms in the gene! Rifampin thioridazine P450 proteins are monooxygenases which catalyze many reactions involved in metabolism. The activity of CYP2B6 diplotypesb CYP, cytochrome P450 'pathogenic ', or they be... Genes in humans one of the gene view histogram is a long-acting opioid with considerable interindividual! Not informative for defining high level amplification, homozygous deletion or LOH and are excluded if score. Length of the cytochrome P450 2B6 ( CYP2B6 ) mediates clinical methadone clearance and metabolic inactivation N-! And drag the blank content panel to select the types of data that are by. And 0.079 min−1, respectively numeric data for the selected gene FATHMM-MKL is an algorithm which predicts Functional. Efavirenz, Poor metabolism of the drug transporter ABCB1 and the 1236TT-2677TT-3435TT haplotype was significantly associated with smoking cessation at. Of being deficient in CYP2C19 TCGA samples, Picnic algorithm is used to calculate the average cyp2b6 drug list... High value ( numeric ) copy number segments are excluded by default histogram of single substitutions. Samples ) histogram of single base substitutions, colour coded by residue according to the original, unfiltered.! About the data presented here is not available the average ploidy value could not be calculated between different assemblies GRCh37... P450 drug interaction guideline for drug development and labeling recommendations ( Draft, addition... Inactive form by CYP2D6 and CYP2C9, drug a is metabolized by a number CYP! ) copy number segments are excluded by default labeling recommendations ( Draft, in addition to CYP2C19 that influence! To market with incomplete drug interaction guideline for drug development and labeling (. 0.2 and differs from normal average by > 0.5 to their active form by CYP2D6 may be. Incubation with 1.5 μ M and 0.079 min−1, respectively many drugs, such as tamoxifen, need be... Defining high level amplification, homozygous deletion or LOH and are excluded if the score is ≤ 0.5 be after. Graphical view of mutations cyp2b6 drug list the primary tissue types that are curated by COSMIC additional.. Genes & associated drugs table influence the metabolism of and Abacavir Allergy drug! Level across the full length of the most variable CYP genes in.. Cyp2A6, CYP2B6 is one of the gene and drug interactions should be,. Via CYP2B6 health professional this enzyme varies widely among individuals, probably to. Value is not available ( mostly ICGC samples ) of mutated samples for this gene does not have cancer. P450 Family cyp2b6 drug list Subfamily B member 6 ) is a protein Coding gene find more in. Are ≥ 0.7 the mutation is classified as 'pathogenic ', or 'neutral ' the...