12, Pages 1766: Endocrine Risk Factors of Endometrial Cancer: Polycystic Ovary Syndrome, Oral Contraceptives, Infertility, Tamoxifen. Vitex negundo (VN), commonly known as "chaste tree", is an ethnobotanically important plant with enormous medicinal properties. Vitex negundo, a medicinal plant of the family ‘Verbenaceae’ and commonly known as chaste tree or five-leaved chaste tree or horseshoe vitex. Crossref Secondly, The CCK-8 and apoptosis experiment results suggested that downregulated miR-... Vitamin D3 action within the ovary - an updated review. Lagundi in Traditional and Folkloric Medicine Lagundi or Vitex negundo has been traditionally used as herbal medicine by Philippine and Indian folks. USA.gov. Offspring sex and risk of epithelial ovarian cancer: a multinational pooled analysis of 12 case –control studies. This is the first review presenting up-to-date information about the VN, its bioactive constituents and their mode of action. Several bioactive compounds obtained from VN have been commercialized and others are under investigation. The role of unopposed estrogen in the development of endometrial cancer has been investigated in numerous studies. Vitex negundo is indicated in Joint Disorder, Low Back Pain, Osteoarthritis, Rheumatoid Arthritis (Amavata), Sciatica, Spondylosis, and Vata Vyadhi.  |  Almost all the sections of the plant possess a massive amount of phytochemical secondary metabolites that impart an unparalleled variety of medicinal uses of the plant. It was observed that methanolic extract of Vitex negundo showed equal activity against both the bacteria with MIC value equal to 5mg/mL. The phytochemical constituents of medicinal plants often function indi-vidually, additively or synergistically in improvement of health [31]. Vitex negundo Linn. Conclusion: There was no difference in the ovarian protective effect according to the difference in the timing of administration of GnRHa. Universal Journal of Pharmacy, 2, 42-46. Tuesday, 12 January 2010. Anti-inflammatory and anti-osteoporotic lignans from Vitex negundo seeds. Balraj Singh Gill, Richa Mehra, undefined Navgeet, Sanjeev Kumar, Vitex negundo and its medicinal value, Molecular Biology Reports, 10.1007/s11033-018-4421-3, (2018). Advanced search can include the following: Vitex negundo and its medicinal value. Natural products are rich in several potent bioactive compounds, targeting complex network of proteins involved in various diseases. Some consider it to have originated in India and the Philippines. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Different species of Vitex vary in chem …. This is the first review presenting up-to-date information about the VN, its bioactive constituents and their mode of action. is a woody plant found mainly in Indian subcontinent and its neighbouring countries. Commonly known in the Ilocos region as dangla, lagundi has been clinically tested to be effective in the treatment of colds, flu, bronchial asthma, chronic bronchitis, and pharyngitis. Mol Biol Rep. 2018 Oct 11;: Authors: Gill BS, Mehra R, Navgeet, Kumar S Abstract Natural products are rich in several potent bioactive compounds, targeting complex network of proteins involved in various diseases. VN, reportedly, perturbs many cancer-signaling pathways involving p-p38, p-ERK1/2, and p-JNK in LPS-elicited cells, N-terminal kinase (JNK), COX-1 pathways, MAPK, NF-κB, tumor necrosis factor α (TNF-α), Akt, mTOR, vascular endothelial growth factor, hypoxia-inducible factor (HIF-1α). Falko P. Drijfhout, E. David Morgan, in Comprehensive Natural Products II, 2010. leaves of Vitex negundo L. was subjected to pharmacological analysis and was explored for possible anti-bacterial activity against Salmonella typhiand Pseudomonmas aeruginosaby agar diffusion method. More than hundred patents were found on its medicinal applications as a rheumatoid arthritis 137 and for skin care 138 etc. Firstly, we found that miR-760 expression was decreased in PCOS tissues insulin treated GCs, KGN and SVOG cells. HHS Vitex negundo (VN), commonly known as "chaste tree", is an ethnobotanically important plant with enormous medicinal properties. Epub 2015 Jan 30. Clarification of their roles in the female reproductive system is crucial to understanding the physiology and pathology of this syste... Adu-Gyamfi EA, Czika A, Liu TH, Gorleku PN, Fondjo LA, Djankpa FT, Ding YB, Wang YX. These bioactive compounds exhibit anti-inflammatory, antioxidant, antidiabetic, anticancer, antimicrobial. 2009 Jun;16(6-7):560-7 Xu JM, Hu BC, Yuan L, Wu YL, Luan SS, Yuan T, Wang D, Chen LX. Vitex negundo (VN), commonly known as “chaste tree”, is an ethnobotanically important plant with enormous medicinal properties. Nirgundi Oil (Vitex negundo) - Benefits, Uses and Properties. Binding of ephrins to the Eph receptors activates signaling cascades that regulate several biological processes such as cellular proliferation, differentiation, migration, angiogenesis and vascular remodeling. Abstract VN is typically known for its role in the modulation of cellular events like apoptosis, cell cycle, motility of sperms, polycystic ovary disease, and menstrual cycle. Vitex negundo and its medicinal value. and on percentage of larval parasitism by Dinarmus vagabundus (Timberlake). Casticin from Vitex species: a short review on its anticancer and anti-inflammatory properties. Vitex arborea Desf. Crossref It;'s main health benefit is to ease respiratory complaints. 2013 Dec 04;13:343 Apoptosis; Cancer; Reactive oxygen species; Signaling; Vitex negundo. Several bioactive compounds have been extracted from leaves, seeds, roots in form of volatile oils, flavonoids, lignans, iridoids, terpenes, and steroids. It is a muscle relaxant and pain relieving herb. Vitex negundo and its medicinal value. -, Anticancer Drugs. Different species of Vitex vary in chemical composition, thus producing different phytochemicals. NCI CPTC Antibody Characterization Program, Phytomedicine. 2004 Nov;52(11):1269-72 Also, there are ten types of EphAs (EphA1-10) and six types of EphBs (EphB1-6). Programmed cell death factor 4 (PDCD4) is originally described as a tumor suppressor gene that exerts antineoplastic effects by promoting apoptosis and inhibiting tumor cell proliferation, invasion, and metastasis. Labdanes and megastigmanes from Vitex negundo var. 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